PKMZ and CREB’s Role in in Memory Formation and Retention (Wiedenmayer)
PKMZ activity promotes early life traumatic memory formation and retention. CREB (cAMP response element binding) is a protein that is also a transcription factor and is used as a neuronal marker to identify candidate brain areas involved in fear memory formation. It’s active form, phosphorylated CREB (pCREB) regulates protein synthesis necessary for synaptic strengthening during learning. PKMZ is a persistently active, memory-related protein kinase (transfers phosphate group) involved in late phase long-term potentiation (or synaptic strengthening). It has been demonstrated to be required for contextual fear memories in the amygdala but not in the hippocampus. Immediate increase in CREB activity in both the hippocampus and the amygdala, along with PKMZ activity in the amygdala after reconsolidation of fear memories play critical roles in fear learning and long-term memory maintenance. Recently, I’ve become more interested in PKMZ because of its multiple roles, including addiction and cue-related memories… Stopped by this poster at SfN and learned that it ties into my current research as well.
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